Abstract: This paper introduced a novel highly effective inorganic antibacterial material technology, which used hydroxyapatite(HAP)as a carrier, co-precipitation and ion-exchange process to prepare titaniummetal ions (Ag⁺ ,Cu²⁺,Zn²⁺) doped hydroxyapatite(HAPTiM). According to the XRD characterization, the optimum doping of Ti/(Ca +Ti)was 0. 1, without changing the structure of HAP. And the materials were further characterized by FT-IR and UV-vis diffuse reflectance absorption spectra. Based on the antibacterial experiment on staphylococcus aureus and escherichia coli, the results showed that the materials have better antibacterial activity than nano TiO₂.

Key words: antibacterial material, Ti(I)/metal ions doped HAP, activity, synergistic effect

摘要： 以羟基磷灰石（HAP）为载体,采取共沉淀和离子交换法制备钛/金属离子(Ag⁺ ,Cu²⁺,Zn²⁺ )复合羟基磷灰石（HAPTiM）无机高效抗菌材料技术,依据XRD表征,确定不改变HAP结构,最佳钛的掺杂量为XTi=Ti原子数/（Ca+Ti）原子数=0.1,并通过UV-vis漫反射吸收光谱对该材料进行了表征。金黄色葡萄球菌和大肠杆菌的抗菌性实验,结果表明:该材料比纳米TiO₂具有更大的抗菌活性。

关键词: 抗菌材料, Ti(Ⅳ)/金属离子复合羟磷灰石, 活性, 协同效应