In order to address the shortage of raw materials and high product carbon footprint（PCF）for petrochemical polyester resin，the effects of different bio-based monomers，such as ethylene glycol，1，3-propanediol，1，2-propanediol，1，4-butanediol，fumaric acid and 1，4-butanedioic acid on the properties of polyester resin and powder coatings were systematically studied，then the bio-based polyester resin SJ3706B for indoor thermosensitive substrates and SJ3B-6B for indoor matting decoration were synthesized by using these rules.The results showed that the performance of bio-based resin was close to that of petrochemical based resin，and some indicators were better than petrochemical based polyester resin，the PCF of bio-based polyester resin was significantly lower than that of petrochemical based resin.