［Objective/Significance］Benefiting from their eco-friendly characteristics，excellent comprehensive performances and versatile tunability，waterborne polyurethane-acrylate（PUA）hybridresins have demonstrated significant application potential in the coating field. Reasonable structuraldesign and modification are critical for advancing waterborne PUA coatings towards high-end applications.［Analysis/Discussion/Progress］This review focuses on waterborne PUA resin systems.On the basis of conventional room-temperature crosslinking systems，the design strategies of multiple crosslinking，one-component room-temperature crosslinking，dynamic covalent interactions and microphase separation structure are systematically discussed. More importantly，the roles of structural design in performance optimization and material recycling are elucidated.［Conclusion/Prospect］ Precise structural regulation and full-life-cycle green development have become the key priorities fordeveloping waterborne PUA hybrid resins，as well as the critical directions for the high-performanceand sustainable development of waterborne PUA coatings.