［Objective］ To address the poor compatibility between vacuum-deposited coatings and polycarbonate（PC）substrates arising from the low surface energy of PC，a silicone-acrylic hybridresin primer for PC vacuum coating was designed and synthesized via molecular structure engineering.［Methods］ The first step involved synthesizing an alcohol-soluble acrylic prepolymer（IPAA） via solution polymerization using MMA，MAA，HPA，KH-570，ABVN，and IPA as primary raw materials. In the second step，an alcohol-soluble organosilicon-acrylic hybrid resin was synthesized via the sol-gel method using MTES，IPAA，and self-made adhesion promoter（FC）as primary raw materials. Theinfluence mechanism of formulation parameters on the comprehensive properties of the coating wassystematically investigated.［Results］ Optimization results indicated that the alcohol-soluble organosilicon-acrylic hybrid resin was successfully synthesized through a two-step process of“radical solution polymerization-sol-gel. ”When FC content was 4wt%，silica sol content was 5wt%，and the MTES/IPAA mass ratio（M/I value） was 1.2，the coating exhibited excellent adhesion，moisture resistance，heat resistance，optical transparency，and coating compatibility.［Conclusion］This primer exhibited excellent adhesion on PC substrates，along with outstanding damp heat resistance and optical properties. The deposited ITO film demonstrated favorable optoelectronic performance，meeting the stringent performance requirements for vacuum-coated PC products.