［Objective/Significance］ Poly（vinylidene fluoride）（PVDF），a high-performance fluoropolymer，is witnessing increasing demand across diverse applications，particularly in specialized coatings and new energy sectors. However，the polymerization of vinylidene fluoride（VDF）presentssignificant challenges due to its inherent heterogeneous nature and highly exothermic reaction，which lead to a strong coupling between the polymerization kinetics and multiphase mass transfer. This complex interplay creates substantial hurdles for industrial-scale reactor design and scale-up.［Analysis/Discussion/Progress］ This review summarizes the advancements in VDF polymerization processes（including emulsion，suspension，solution，and supercritical polymerization），reactor design（covering batch reactor，tubular reactor and other new types of reactors），and associated modeling studies.［Conclusion/Prospect］ Our aim is to provide valuable insights for the efficient，safe，and industrial-scale production of high-performance PVDF，while also promoting the continuous upgrade of related engineering technologies.