［Objective］ To enhance the mechanical strength of self-healing polyurethane containing disulfide bonds，a high-strength and high-resilience self-healing polyurethane elastomer（PU）based on disulfide bonds and multiple hydrogen bonds was prepared.［Methods］A prepolymer was first prepared by the reaction of polytetrahydrofuran（PTEMG） with isophorone diisocyanate（IPDI）. The prepolymer was then further reacted with 4，4'-diaminodiphenyl disulfide（4-AFD）to synthesize an intermediate. Finally，the intermediate reacted with isophthalic dihydrazide（IPDH）to form polyurethane（PU）. The influence of the molar ratio of soft and hard segment monomers on theproperties of PU was investigated. The products were characterized using Fourier transform infraredspectroscopy（FT-IR）， X-ray diffraction（XRD）， thermogravimetric analysis（TG）， and differential scanning calorimetry（DSC）.［Results］The polyurethane with a molar ratio of soft segments（PTEMG）to hard segments（including IPDI，4-AFD，and IPDH monomers） of 2.5（PU2. 5） possessed goodhardness and resilience. It exhibited a self-healing efficiency of 54% at 80 ℃ . Moreover，the self-healed PU2. 5 exhibited high elongation at break（827%）and tensile strength（8 MPa）.［Conclusion］ The synthesized polyurethane elastomer exhibited good self-healing and mechanical properties.