［Objective］To develop hydroxyacrylic latex with excellent compatibility for coating applications.［Methods］ Monodisperse hydroxyacrylic latex was successfully synthesized via pre-emulsification process combined with in-situ variable-speed feeding technology. Through molecularstructure optimization，the polymer’s relative molecular weight and glass transition temperature（T_g） were precisely controlled. Fatty acid ester-based acrylate crosslinker（FAE-CA） and reactive surfactants were incorporated to prepare different latex formulations. The latex swelling behavior duringpaint formulation，along with its compatibility with curing solvent［propylene glycol monomethyl ether acetate（PMA）］ and film-forming additives［diethylene glycol butyl ether（DB）and propylene glycol butyl ether（PNB）］ were investigated systematically.［Results］ Adjusting the number-average molecular weight to approximately 5 000 and designing T_g at 50 ℃ significantly facilitated film formation，which can improve latex swelling by film-forming additives. The incorporation of FAE-CAcrosslinker enhanced the compatibility of latex with PMA，with the optimal compatibility achieved at 5% usage；while replacing anionic surfactant with reactive surfactant ReactSurf2490 further improvedcompatibility with film-forming additives.［Conclusion］ The developed well-compatiblehydroxyacrylic latex demonstrated outstanding comprehensive performance after paint application： defect-free smooth surfaces with a 60° gloss >95，a pencil hardness of 2H，adhesion rated as grade 0 and successful passage of 7-day water resistance test.