［Objective］ To develop green and environment-friendly antibacterial resin.［Methods］Herein，we report the design and synthesis of a green，intrinsically antifouling polyoxime urethane elastomer（PCDU）by incorporating a bio-based，furan-functionalized chain extender with inherent antibacterial activity.［Results］ The resulting PCDU exhibits outstanding mechanical properties（tensile strength up to 4. 03 MPa and elongation at break of 430%）， along with excellent antibacterial efficacy（100% inhibition within 24 h）and antifouling performance（nearly zero adhesion of algae and proteins）.［Conclusion］ A green and environment-friendly intrinsically antibacterial polyoxime urethane was prepared，which provided a certain reference value for the subsequentdevelopment of intrinsically antibacterial marine coatings.