Epoxy ester prepolymer was synthesized by esterification of unsaturated fatty acids，acrylic acid and epoxy resin，and copolymerized with dodecafluoroheptyl methacrylate（DFMA）and vinyl monomer by semi-continuous radical polymerization process to synthesizeaqueous fluorinated hybrid acrylic resin dispersion. The dispersion and film were characterized byFourier infrared spectrometer（FT-IR），energy dispersive spectrometer（EDS），thermogravimetry（TGA）differential scanning calorimeter（DSC）gel permeation chromatograph（GPC）contact anglemet，erandlaserparticlesizeanalyzer.The，effects of esterification temperature，e，poxyester dosage DFMA and initiator dosage on resin properties were systematically studied，and the cross-linking curing mechanism was further explored. The results showed that DFMA could copolymerize with vinyl monomer to form fluorinated acrylic resin. When the DFMAmonomer dosage was 9%，the particle size of the resin dispersion was less than 125 nm， showing uniform distribution and good storage stability. The water contact angle reached 96. 5 °，the adhesion was level 0，and the 10% thermal weight loss temperature exceeded 336 ℃ . At the same time，water resistance，acid resistance and alkali resistance of the film were significantly improved， effectively enhancing the comprehensive properties of conventional water-borne acrylic resin dispersion.