The research on advanced smart bacterial coatings plays a vital role inprotecting bacteria contamination in the field of medical instrument and public environment.Based on the radical polymerization of alkyl acrylate and methacrylate-functionalized β-cyclodextrin and hydroxyl phosphate as monomers，the copolymer coatings with host-guest interaction and strong adhesion are synthesized. The low-molecular antibacterial agent（thymol，THY）was selected as guest molecule to be included into the cavity of β -CD in copolymers. In that case，the smart controlled releasing triggered by acidic condition（pH=5） can be observed，that is，THY could be gradually released through the reversible host-guestinteraction. The results indicated that the copolymers coatings could sufficiently restrain thegrowth of escherichia coli（E. coli） and staphylococcus aureus（S. aureus）. Especially，the antibacterial rate of copolymer coatings against S. aureus reached about 100% as the content of β -CD units is 45% in copolymer backbones. In addition，the coatings exhibited good adhesion to various substrates. The adhesion by put-off test can exceed 10 MPa. The preparation of these copolymer coatings provided one effective route to fabricate smart antibacterial coatings.