In order to reduce bacterial damage to materials，new environmentally friendlyUV curable antibacterial coatings was prepared. In this paper，a silicone quaternaryammonium salt antibacterial agent（QAC） was synthesized by a one-step quaternization method. SiO₂ nanogel was used as the carrier，and QAC and silane coupling agents containingacrylic acid double bonds were added to the nanogel in different proportions to obtain a newUV curable organic-inorganic hybrid quaternary ammonium salt antibacterial agent（UV-SiO₂-QAC）. The UV curable antibacterial coatings was prepared by using epoxy acrylate and UV-SiO₂-QAC. The structure of QAC was determined by using H nuclear magnetic resonance（¹H NMR） and fourier transform infrared spectroscopy（FT-IR）. The apparent morphology and thermal properties of the coatings were determined by using scanning electron microscopy（SEM）， thermogravimetric analysis（TGA）， and differential scanning calorimetry（DSC）. The antibacterial properties，double bond conversion，hardness，and tensile strength of the coatingwere tested. The results showed that using antibacterial agent with a molar ratio of QAC tosilane coupling agent of 1∶ 1，the coating had the best antibacterial effect against Staphylococcus aureus at a dosage of 10%. The antibacterial zone reached 12. 5 mm at 0 day and 11.4mm at 5day，the pencil hardness was 2B，the tensile strength was 3. 72 MPa，double bond conversion rate was 81%. The comprehensive performance was the best.