【目的 /意义】水性聚氨酯丙烯酸酯（ PUA）杂化树脂凭借绿色环保、优异的综合性能及性能可调性，在涂层领域展现出巨大应用价值。合理的结构设计和改性，是推动水性 PUA涂层迈向高端应用的关键。【分析/评论 /进展】本文聚焦水性 PUA树脂体系，在常见室温交联体系的基础上，重点讨论了多重交联、单组分室温交联、动态共价作用、微相分离结构的设计策略，同时阐明了结构设计在性能优化和材料循环利用方面的作用。【结论 /展望】结构精准调控与全生命周期绿色化是开发水性 PUA杂化树脂的重点，也是水性 PUA涂层向高性能化、可持续化方向发展的关键。

［Objective/Significance］Benefiting from their eco-friendly characteristics，excellent comprehensive performances and versatile tunability，waterborne polyurethane-acrylate（PUA）hybridresins have demonstrated significant application potential in the coating field. Reasonable structuraldesign and modification are critical for advancing waterborne PUA coatings towards high-end applications.［Analysis/Discussion/Progress］This review focuses on waterborne PUA resin systems.On the basis of conventional room-temperature crosslinking systems，the design strategies of multiple crosslinking，one-component room-temperature crosslinking，dynamic covalent interactions and microphase separation structure are systematically discussed. More importantly，the roles of structural design in performance optimization and material recycling are elucidated.［Conclusion/Prospect］ Precise structural regulation and full-life-cycle green development have become the key priorities fordeveloping waterborne PUA hybrid resins，as well as the critical directions for the high-performanceand sustainable development of waterborne PUA coatings.