为探究天然产物基防污涂料在水产养殖设施上的应用效果，以喜树碱（ CPT）为防污剂制备了海洋防污涂料，开展了其对水生生物卤虫的毒性检测实验以及在养殖网衣上的海区应用试验。结果表明：含 CPT（5%~20%）的防污涂料对卤虫没有显著毒性，且在珠母贝养殖笼具上的防污性能良好，期效达 120 d以上，其中含 CPT（5%）的涂料对合浦珠母贝生长和存活均没有显著影响； CPT（1%）和溴代吡咯腈（ 5%）复配的涂料在鱼类养殖网衣上的防污期效大于 180 d，且对黄鳍鲷的生长和存活均没有显著影响。本文揭示了天然产物 CPT在水产养殖设施的防生物污损方面具应用潜力。

In order to explore the effect of application of natural product-based antifouling coatings on aquaculture facilities，we prepared the marine antifouling coatings using the natural product camptothecin（CPT）as antifoulant，tested their toxicity to the aquatic organism Artemia salina and applied them to the aquaculture nets in the sea. The resultsshowed that the antifouling coatings containing CPT（5%-20%）had no significant toxicity to A. salina. They showed good antifouling performance on the net cages which were used forculturing the pearl oyster Pinctada fucata，with the antifouling efficiency lasting for 120 days. The coating containing CPT（5%）had no significant effect on the growth and survival of P. fucata. Furthermore，it was found that the coating containing CPT（1%）and tralopyril（5%） exhibited antifouling efficiency over a period of 180 days and had no significant impact on thegrowth and survival of the yellowfin seabream Acanthopagrus latus. This study revealed theapplication potential of the natural product CPT in biofouling control for aquaculture facilities.